Publikasi Dosen

Cytotoxic and Antioxidant activity of Petroleum Extract of Andaliman Fruits (Zanthoxylum acanthopodium DC.)

Abstract
Cancer is a growing health problem coming next to the stress oxidative diseases. The objectives of this study were to investigate potential in vitro cytotoxic effect on breast cancer cell line T47D and antioxidant
activity of the petroleum extract of Zanthoxylum acanthopodium (Andaliman) fruits. Andaliman is a wild spices well known in North Sumatera, Indonesia for Batak’s traditional cuisine. The activity of this extract to inhibit
the growth of breast cancer T47D cells was determined by MTT assay with doxorubicin HCl as standard. Free radical scavenging potential was determined by in vitro evaluation against DPPH and xanthine oxidase. The
results revealed that petroleum extract of andaliman fruits was active as xanthine oxidase inhibitor with IC50 9,9 µg/mL and possessed cytotoxic activity on T47D cell line with IC50 149,4 µg/mL.
Keywords: Antioxidant, cytotoxic, xanthine oxidase, Zanthoxylum acanthopodium DC.

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

001

Penerbit

International Journal of Pharm : International Journal of PharmTech Research., 2014

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

001

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

2021

Subjek

Antioxidant, cytotoxic, xanthine oxidase, Zanth

Info Detail Spesifik

International Journal of PharmTech Research ; CODEN (USA): IJPRIF ISSN : 0974-4304 ; Vol.6, No.3, pp 1064-1069, July-Aug 2014 ; Author : Ruth Elenora Kristanty, Junie Suriawati - Department of Pharmacy and Food Analysis, Health Polytechnic Health Ministry Jakarta II, Jakarta 12540

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