Publikasi Dosen

Isolation of antioxidant and xanthine oxidase inhibitor from n-Butanol extract of Andaliman fruit (Zanthoxylum acanthopodium DC.)

Abstract:
The fruits of andaliman (Zanthoxylum acanthopodium DC.) are well known in North Sumatera, Indonesia and commonly used in Batak traditional cuisine. This research was conducted to isolate and elucidate the compounds from the fruits which have antioxidant and xanthine oxidase inhibitory activity. Based on spectrum data, the compounds obtained from n-butanol extract were polar terpenoids. They are 17-((23E,26E)-23- ethylidene - 29 - hydroxy - 29-(2- hydroxypropoxy)-25-methyldec-26-en-20-yl)-13,15-dimethyl-gona-1,3,5(10)-trien-3-ol and cholest-5-en-3β-yl β-D- glucopyranoside. Free radical scavenging potential of those compounds had been investigated by in vitro evaluation against DPPH and xanthine oxidase. The results showed that they are active as antioxidant with IC50 68.35 µg/mL and 60.52 µg/mL and also active as xanthine oxidase inhibitor with IC50 0.34 µg/mL and 0.06 µg/mL.
Keywords: Antioxidant; free radical; xanthine oxidase; Zanthoxylum acanthopodium DC.

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Informasi Detail

Judul Seri

-

No. Panggil

001

Penerbit

: Int. J. Med. Arom. Plants., 2012

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

001

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

2021

Subjek

Antioxidant; free radical; xanthine oxidase; Z

Info Detail Spesifik

International Journal of Medicinal and Aromatic Plants 2 (3), 376-389; Author : Ruth Elenora Kristanty-1, Abdul Mun'im-2, Kartrin-2 --- 1. Jurusan Analisa Farmasi dan Makanan- Politeknik Kesehatan Jakarta II, Indonesia; 2.- Fakultas Farmasi, Universitas Indonesia ;ISSN 2249 – 4340 Vol. 2, No. 3, pp. 376-389, September 2012

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