Publikasi Dosen

Preparation and Characterization of Gliclazide Solid Dispersion in Binary and Ternary System

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ABSTRACT
Objective: The objective of this research was to improve the dissolution rate of gliclazide by solid dispersion technique with poloxamer 188, HPMC, and Eudragit®
Methods: Solid dispersions were prepared by solvent evaporation methods in the binary and ternary system. In binary system gliclazide was mixed with poloxamer188 in the ratio of 1:0.5, 1:0.75, 1:1, 1:1.5 and 1:2, with HPMC in the ratio of 1:0.1, 1:0.125, and 1:0.25, and with Eudragit E100 as carriers.
® E100 in 1:0.25 ratio. In ternary system gliclazide was prepared with poloxamer188 and HPMC in the ratio of 1:2:0.1 and 1:2:0.25, and with poloxamer188 and Eudragit®
Results: At the 15 E100 in the ratio of 1:1:0.25 and 1:2:0.25. Pure gliclazide, solid dispersions, and physical mixtures were characterized by dissolution testing, DSC, FTIR, dan XRD.
th minute, the highest dissolution rate observed from binary and ternary solid dispersions of gliclazide were from gliclazide-poloxamer188 1:2 dan gliclazide-poloxamer188 and Eudragit®
Conclusion: The results of this study E100 1:2:0,25 which showed 12 and 15 fold increase in dissolution rate compared by pure gliclazide. The decrease of endothermic peak (DSC) and the intensity of the diffraction pattern by XRD of solid dispersions showed the decrease of crystallinity rate. Characterization by FTIR virtually showed no shift of absorption peaks of gliclazide on solid dispersion.
indicate that the solid dispersion of gliclazide using poloxamer and Eudragit®

Keywords: Dissolution, Gliclazide, Solid dispersions, Poloxamer 188, HPMC, EudragitE100 in 1:2:0, 25 ratio of weight was the best in enhancing the dissolutions characteristics and bioavailability.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

001 War p

Penerbit

: International Journal of Pharmacy and Pharmaceutical Sciences., 2016

Deskripsi Fisik

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Bahasa

English

ISBN/ISSN

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Klasifikasi

001

Tipe Isi

-

Tipe Media

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Tipe Pembawa

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Edisi

2016

Subjek

Dissolution
Gliclazide
Poloxamer 188
Solid dispersions
HPMC

Info Detail Spesifik

International Journal of Pharmacy and Pharmaceutical Sciences ;ISSN- 0975-1491 Vol 8, Issue 8, 2016

Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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