Karya Tulis Ilmiah

Penetapan Kadar Hidroklorotiazid Dalam Sediaan Tablet Secara Kromatografi Cair Kinerja Tinggi

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Adinda, "Determination of Hydrochlorothiazide Levels by High Performance Liquid Chromatography Tablet dosage form", under the guidance of Dian Maria Ulfa, M.Farm, Apt., And Dra Nita Ristiawati, M.Sc., Apt., 2019.
Hydrochlorothiazide is an antihypertensive drug used to treat hypertension. All of these drugs must have the required quality before being circulated and consumed by the patient. This drug must be tested to determine its quality. One of the test that needs to be done is the level determination. This test aims to determine hydrochlorothiazide levels in tablet dosage form using High Performance Liquid Chromatography (HPLC) with C18 column (25 cm column length, 4.6 mm inner diameter) and isocratic mobile phase in the form of a mixture of monobasic phosphate P: Acetonitrile P (9: 1), flow rate of 2.0 mL / minute, UV-Vis detector λ 254 nm. Samples were tested twice. Based on experiments and calculations that have been done, the average level of hydrochlorothiazide in tablets is 94.85% and RSD is 0.7847%. So, it can be concluded that the sample meets the requirements according to the monograph requirements of Hydrochlorothiazide tablets in Indonesian Pharmacopoeia Edition V 2014.
Keywords: hydrochlorothiazide, anti-hypertension, high performance liquid chromatography

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

001.43 ANF-D3- 2019 Adi p

Penerbit

Jakata, Poltekkes Jakarta II : Jurusan Analisis Farmasi dan Makanan., 2019

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

001.43

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

2019

Subjek

hydrochlorothiazide
anti-hypertension
high performance liquid chromatography

Info Detail Spesifik

Dian Maria ulfa (P1), Dra.Nita Ristiawati (P2), D3-ANF

Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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